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To our knowledge, this question has never been addressed, possibly because the highly dynamic reuterin system is challenging to analyze in a quantitative manner, even without accounting for the potential formation of acrolein

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Xenobiotic metabolism and disposition in human lung: transcript profiling in non-tumoral and tumoral tissues

Local (and systemic) estradiol can stimulate lesion production of PGE2, which can activate pain fibers, enhance neuronal invasion of lesions by stimulating production of NGF and other neurotrophins, and promote sprouting of nociceptors that contribute persistent inflammatory pain and inhibit neuronal apoptosis