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Other constituents, such as vinyl chloride, have a well-established association with hepatic angiosarcoma [28], whereas cadmium enhances liver cancer risk through proto-oncogene activation, oxidative stress induction, and stimulation of pro-inflammatory cytokines [29,30,31]

The effect of residence time on chemisorption of mainstream smoke toxicants by the chemisorbent CR20 has been discussed previously, wherein kinetic analysis demonstrated that a fixed CR20 bed has diminished toxicant stripping properties under enhanced flow rate conditions (Branton et al.2011b)

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