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During neurodegenerative processes, microglial activation is frequently observed, with increasing evidence suggesting that iron overload and disrupted iron homeostasis contribute to neurodegeneration in AD (47,48)

Annu Rev Pathol

Thus, amygdalin has been shown in vitro experiments to induce apoptosis due to upregulated expression of caspase-3 and Bax protein and downregulated expression of Bcl-2, an anti-apoptotic protein (217) ( Table 2 )