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As discussed in the 2010 Surgeon General report, the ongoing research is contributing to further improvements in the understanding of the neurobiology and role of tobacco product design factors in tobacco addiction, as well as advances in the diagnosis and treatment of addiction and withdrawal as described in the fifth edition of the American Psychiatric Association's Diagnostic and Statistical Manual (American Psychiatric Association 2013)

Fiscal Impact Proposition 31 likely would reduce state tobacco tax revenues by an amount ranging from tens of millions of dollars per year to around $100 million annually, according to the Legislative Analysts Office (LAO)

23 , e147e153 (2014)

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