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Among participants with zero APOE-4 allele, 0.89% (95% CI 0.731.08%) current and 0.64% (95% CI 0.580.71%) former smokers developed dementia compared with 0.49% (95% CI 0.440.55%) of never smokers (adjusted HR 1.78

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By choosing appropriate nicotine strengths, avoiding excessive use, and paying attention to early warning signs, users can significantly reduce their risk

It's also worth considering nutritional deficiencies, particularly zinc, vitamin B12, iron and vitamin A, as these nutrients all support healthy nerve function and smell