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Other non-hormone treatments that may help you manage hot flashes include: Elinzanetant (Lynkuet) and fezolinetant (Veozah), medicines that help you regulate your body temperature Selective serotonin reuptake inhibitor (SSRI) antidepressants, such as: Citalopram (Celexa) Desvenlafaxine (Pristiq) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva), including a low-dose form (Brisdelle) that is FDA-approved to treat hot flashes Venlafaxine (Effexor) Other prescription medicines that are used "off-label" (which means that they aren't FDA-approved for hot flashes but are used because they're effective) include: Clonidine (Catapres, Kapvay), a high-blood pressure medicine Gabapentin (Neurontin, Gralise), an anti-seizure medicine Oxybutynin (Ditropan XL, Oxytrol), an overactive bladder medicine Pregabalin (Lyrica), another anti-seizure medicine Hot Flash Prevention Theres nothing you can do to completely prevent hot flashes around menopause