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Finally, the four ACAT-combined p-values from BURDEN, SBAT, SKATO, and ACATV were further combined using ACAT to produce a single GENE-P value, providing a comprehensive assessment of genetic associations within each gene

Unfortunately, sometimes this happens accidentally: Many of us have made the mistake of stepping on a bee or gone too close to a bee hive without proper precaution

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And there may have been a practical side to my tenacity as well