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found the flavorings in e-liquids can trigger an inflammatory response in monocytes, mediated by reactive oxygen species (ROS) production, which leads to dose-dependent cytotoxicity [47]

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For more on the FDAs premarket review process for e-cigarettes, see the Public Health Law Centers factsheet, Extensions and Epidemics: The FDAs Gatekeeping Authority for E-Cigarettes and see updates on the FDA decisions on their Tobacco Product Applications: Metrics & Reporting page as well as on their Tobacco Product Marketing Orders page

The FDA has specifically named Juul as a company whose marketing practices concern them