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Among current female smokers, "the chance of dying from heart disease or lung cancer exceeds the chance of dying from breast cancer from 40 on (and does so by at least a factor of 5 after age 55)." [17] The habit becomes particularly crucial when women are also taking birth control because these two in concert increases, even more so, women's chances of having a stroke or a heart attack

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This is why a 'nicotine test' may actually be a 'cotinine test' or even a test for anabasine (a tobacco-specific alkaloid not present in nicotine replacement products)