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[95] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain

doi: 10.1136/bmj.l5275 Summary Keywords E-cigarettes, health effects, tobacco harm reduction, chronic effects of vaping, systematic review Citation Izquierdo-Condoy JS, Naranjo-Lara P, Morales-Lapo E, Hidalgo MR, Tello-De-la-Torre A, Vsconez-Gonzles E, Salazar-Santoliva C, Loaiza-Guevara V, Rincn Hernndez W, Becerra DA, Gonzlez MBD, Lpez-Corts A and Ortiz-Prado E (2024) Direct health implications of e-cigarette use: a systematic scoping review with evidence assessment