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Design and analysis of cross-over trials, 3rd ed: CRC Press

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Social acceptability In some settings, smoking cigarettes may be less socially acceptable than using the IQOS device to consume Heets

For multivariable (MV) MR, Inverse-Variance-Weighted (IVR) Egger MVMR regression 59,60 , and Q-statistic minimization approach were performed using the MVMR R package v0.4, MVMR Ridge regression, a method that uses Ridge regression to shrink the regression estimates was also used 61