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Most Addictive Substances Ranked Harvard researchers help explain link between emotion and addictive substance use Harvard Kennedy School New Poll Shows U.S. Adults Find Cigarettes Most Unsafe, Addictive Substance Southern Iowa Mental Health Center Nicotine is highly addictive and affects both the brain and body. Whether it's vaping or smoking, nicotine can lead to dependence, cravings, and serious health risks over time. Understanding how nicotine works
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