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While the findings were consistent with the hypothesis that semaglutide might be beneficial for smoking cessation, the authors say study limitations preclude firm conclusions and should not be interpreted to justify clinicians use of semaglutide off-label for smoking cessation

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The evidence is clear that combination approaches outperform single-product attempts, and that matching the product to your specific habits, strength needs, and lifestyle is the difference between a quit attempt that sticks and one that doesn't