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The premise of tobacco harm reduction is to offer cigarette smokers who are unable to quit smoking, nicotine delivery systems that produce less harmful chemicals, enabling the user to continue their nicotine exposure when switching entirely to the alternative product, and ultimately, reduce the occurrence of tobacco-related diseases 110

GK: Conceptualization, Funding acquisition, Writingoriginal draft, Writingreview and editing

[146], an increased risk of idiopathic male infertility was reported in male smokers who were carriers of the 462Ile/Val genotype of the CYP1A1 gene (OR=1.91