Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al
Pharmacological mechanisms The pharmacodynamic mechanism of benzodiazepine tolerance and dependence is probably homoeostatic down regulation of gamma-aminobutyric acid and benzodiazepine receptors in the limbic system.(28) Once this has occurred, withdrawal of the drug results in a state of underactivity of pathways utilising gamma-aminobutyric acid with a pattern of unapposed neuronal excitation characteristic of benzodiazepine withdrawal(29) and anxiety states.(10) Similar brain mechanisms mediate the psychological and somatic symptoms of both conditions, which are in many respects inseparable
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Honey is a high biosecurity risk in New Zealand and therefore honey and bee products are strictly prohibited
