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Vitamin B6 can cause neuropathy (nerve damage) if youre getting a very high dose for a long period of time, Romito cautions

Subsequent cytokine release from necrotic cells amplifies renal inflammation, potentially triggering acute kidney injury and accelerating CaOx crystal retention

10.1016/j.cell.2011.02.013 37 HayN

Additionally, we observed that immature neurons themselves also expressed RGMa, raising the possibility that cis-signaling by RGMa-neogenin may also affect the differentiation capacity of immature neurons