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In Uruguay, for instance, the Ministry of Public Health reported a 25% decline in daily smoking among adults between 2019 and 2024, following the implementation of strict advertising bans and plain packaging laws

Initially it was considered by the Europeans to be the sacred herb because of its presumed medicinal properties, but as soon as its importation was increased sufficiently by the Spanish and Portuguese, who developed a monopoly in the sixteenth century on the trade with South and Central America, its popularity began to expand and spread geographically

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It is also worth noting that trichomes have an important function in the accumulation of metals in tobacco leaves