johnny depp tobacco Actor Depp, 37, rolls a cigarette as he arrives for the premiere of his latest film Blow, based on the true story of a notorious drug smuggler, in London's Leicester Square. * Pinterest

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Evidence Against the Gateway Hypothesis The strongest evidence challenging gateway drug theory as a universal mechanism includes: The National Institute of Justice (2018), after reviewing 23 peer-reviewed studies, concluded no causal link between cannabis use and other illicit drug use can be established, noting that statistical correlation persists across populations but direct pharmacological causation cannot be claimed from observational data alone

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