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In summary, our in-silico trajectory analysis suggests a developmental lineage of human secretory cells, driven by sequentially activated TFs, which transitions through functional intermediates (club cells) to culminate in a multi-functional mucus secretory cell 29,30,31,32 , although all cells in this lineage need not reach this mucus secretory endpoint, depending on internal or external differentiation cues

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The results add to evidence of the public health benefits of smoking bans, which have already been shown to reduce tobacco-related illnesses, said Kelly Young-Wolff, the studys lead author, Other Yale researchers contributing to the study were Rani Desai, Jody Sindelar, and Corey E