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It isnt an altogether unenjoyable mix of flavors, but it doesnt have the harmony that the first two thirds of the cigar showcases

These chemicals irritate the delicate tissues of the respiratory system, leading to: Chronic Obstructive Pulmonary Disease (COPD): Smoking is the primary cause of COPD, a group of diseases including chronic bronchitis and emphysema that make breathing increasingly difficult

In most cases, hives are caused by an allergic reaction to a medication or food or are a reaction to an irritant in the environment

The scene also tapped into a broader internet trend of alien-encounters-mundane-human-things comedy, but the specific escalation to "500 cigarettes" gave it a punchline that worked as a standalone catchphrase outside the original context