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the GSMR method was implemented in the GCTA (Genome-wide Complex Trait Analysis) software ( Reported results and interpretation of findings MR IVW odds ratios (OR) with 95% CI, per unit increase in the exposures (e.g., per unit increase of log-transformed alcoholic drinks per week or lifetime smoking index), with P -values derived from two-sided tests, corrected for outlier or invalid variants, are presented in Tables 15