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Interestingly, various crucial cancer-related genes, such as AHRR , CYP1A1 , TNF , SMARCA4 , CDK6 , RARA , RXRB , CDKN1A , RARG , and NFE2L2 , were enriched in the aryl hydrocarbon receptor signaling pathway (Supplementary Table S5), through which abnormal epigenetic programming may trigger smoking-attributable cancer (Fig

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