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These findings suggested that because CS directly affects the ET and ME mucosa, bacterial OM can develop to a more severe stage and may resolve more slowly in the presence of CS exposure rather than in its absence

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Tooth shifting or loss An infection of the gums can develop into more serious periodontal disease, affecting not only the gums but the jawbone

Therefore, we hypothesized that CSE-induced impairment of mitochondrial function is regulated in a HIF-dependent manner and that targeting HIF might represent an interventional strategy against mitochondrial dysfunction