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Key Observations: The evolution from Bonsacks 200 cigarettes per minute to todays 20,000 cpm automated lines has fundamentally reshaped how the tobacco industry manufactures and distributes product, and it has done so while global consumption patterns move in the opposite direction across most developed markets

35 Regardless, the American Academy of Pediatrics recommends off-label NRT for youth who are moderately or severely addicted to nicotine because NRT is considered safer than continued cigarette and/or e-cigarette use