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In the very next episode after the Brian-less outing, Stewie used his old time machine to go back in time and prevent Brian's death, putting a swift end to the show's Vinny era (which, of course, had been the plan all along)

Obesity concerns were used in tobacco advertising since the 1920s, and it's worth noting that the sugar industry copied tobacco's tactics to even greater success (to the point where they had people sympathetic to them on the board of the American Dental Association, while Big Tobacco had much more trouble getting their guys on similar medical boards)

He tells them a story about a bad motherfucker known as Stagger Lee