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Plain packaging rules were first introduced in Australia in 2012, where legal challenges similarly had to be overcome

The policies restricting where people can smoke have made cigarette use less socially acceptable and less convenient, and thus, have encouraged cessation and discouraged uptake of smoking (Gilpin 2004

Functional interactions often involve specific hydrogen bonds and, in some cases, salt bridges, whereas nonfunctional interactionslacking evolutionary selectionare primarily driven by hydrophobic effects 63

22 There is some concern that H2 receptor antagonists and proton pump inhibitors may cause stomach cancer with long-term use