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These pathophysiological changes may ultimately lead to airway remodeling, excessive mucus secretion, and fibrosis, thereby contributing to COPD progression [37]

This study was supported by the Estate of Dr Clem Jones AO, the State Government of Queensland and the Federal Government of Australia (ACT900116), and by grants from the Australian Research Council (DP130101932, LE130100078) and the National Health and Medical Research Council of Australia (GNT1037746, GNT1003150, GNT1127999) to JG

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The company, which has long promoted its nicotine pods as a safer alternative to traditional cigarettes, must provide a written response to the FDA within 15 days