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The remaining sample of never smokers still likely retains some meaningful variation in liability for smoking onset that is not a consequence of e-cigarette use and due to other sources (e.g., social acceptance of smoking, residential proximity to tobacco product retailers)

At far left is a Hanna-Barbera production cel from a 1960 commercial featuring Fred Flintstone lighting up with Stone-Age technology

Such a diffuse association is in keeping with reported negative associations between smoking and cognitive ability shown in the LBC1936 (ref