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Studies of early stages of cancer development have resulted in the theory that cancer arises in areas with cellular genetic alterations associated with malignancy

Acknowledgements Research in the Hecht laboratory is supported by grants from the US National Institutes of Health, the American Cancer Society and the Flight Attendant Medical Research Institute

Next, two 4-m-thick paraffin-embedded sections of the TMA blocks were transferred to electrically charged Star Frost TM (Braunschweig, Germany) slides and incubated with a primary anti-nuclear factor kappa B (NF-B) p105/50 (ab797