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Indeed, when nicotine is administered concurrently with a CYP2A6 inhibitor of unknown strength, the substrate metabolism will be reduced, resulting in increasing serum concentrations and heightened risk, incidence, and/or severity of ADRs

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Because traditional toxicity testing, which involves animals or living cells grown on a flat surface, can take weeks or months to produce high-quality and clinically relevant data, regulatory bodies are struggling to keep up and test products safety in a timely manner

Jonathan Foulds, Departments of Psychology and Public Health Sciences