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Emerging evidence indicates that insufficient maternal folate levels during pregnancy may increase the risk of ASD in offspring, whereas folate supplementation has been associated with reduced neurotoxicity, enhanced neurodevelopment, and attenuation of ASD-related symptoms ( 4.4 Trace elements and nutritional supplementation Children with ASD commonly exhibit elevated oxidative stress, characterized by a reduced glutathione-to-oxidized glutathione (GSH/GSSG) ratio and increased levels of malondialdehyde (MDA), a marker of lipid peroxidation (Lee et al., 2021

The human milk stem cells (hMSCs) likely play an important role in the regeneration of the breast in preparation for lactation and theoretically in the infants tolerance of maternal cell antigens as these cells from human milk do establish a microchimeric state in the infant

Studies have found that higher levels of lutein and zeaxanthin in the diet are associated with a lower incidence of AMD

The study highlights the involvement of the ferroptosis pathway and the modulation of key markers such as FTL, PTGS2, and GPX4 in iron-induced kidney cell death (Figure 9)