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Earlier studies identified Fusobacteria to be metabolically hyperactive in the oral community of OSCC patients ( Prevotella species such as Prevotella intermedia and Prevotella nigrescens with oral inflammations like periodontitis has been reported ( Arecoline, a component of areca nut, has been shown to induce several pro-carcinogenic changes, including the production of nitrosamines and reactive oxygen species ( Capnocytophaga , Prevotella , Selenomonas , Actinomyces , Veillonella , Peptostreptococcus , Granulicatella , Campylobacter , Pseudomonas , and Catonella were among the top 10 genera in tobacco products, and these were differentially abundant in OSCC samples

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