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The protocol has the approval of the Animal Experimental Ethical Committee of Fudan University (2019 Huashan Hospital JS-112) and all animal studies were performed in accordance with the guidelines for the care and use of laboratory animals set by Fudan University (Shanghai, China)

For certain products, such as nicotine gum or lozenges, a tapering approach is suggested: users start with a higher frequency or dosage and then gradually decrease use over several weeks