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The t -statistic is defined as: The corresponding degrees of freedom ( df ) are approximated using the WelchSatterthwaite equation: After obtaining the t -statistic and degrees of freedom df , the P -value is determined by querying the two-tailed cumulative probability function of the t -distribution: where T is a random variable following the t -distribution with df degrees of freedom

Wills et al., 2016c), the differential loss to followup would have resulted in selection bias that most likely would have suppressed the magnitude of the association of the individual articles reviewed for the meta-analysis

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