Widely prescribed to womem Injecting: Started after the invention of hypodermic needle in 1853 Intravenous use takes 15-30 seconds Subcutaneous/intramuscular takes 3-5 minutes Snorting: Self-limiting method The more snorted, the less absorption due to constriction of capillaries in the nose Destructive to nasal passages COCAINE: Routes of Administration Mucosal & contact absorption Can be absorbed through mucosal tissue in nose, mouth, rectum & vagina Delivery method is also used for dental work, minor surgeries Smoking: First introduced in 1914, but high temperature was needed to keep cocaine cigarettes going Mid-1970s, cocaine hydrochloride was chemically altered into freebase Fastest form to reach brain Highly addictive COCAINE: Physical and Mental Effects Metabolism: Quickly metabolized and disappears faster than methamphetamine Medical Use: Only naturally occurring local anesthetic Used to numb nasal passages, eyes, throat, and chronic sores Neurochemistry & Central Nervous System Forces relase of norepinephrine, epinephrine and dopamine Blocks re-absorption so more intense stimulation Blocks 60-70% of dopamine reuptake Too much dopamine can over stimulate brains fright center causing paranoia
"The increase in the proportion of smokers using menthol cigarettes is the result of a tobacco industry innovation which involved the insertion of one or more flavour-changing capsules into the filter
The only issue I can think of is with the air holes
Its best to use a specialized smoke odour remover product thats designed to destroy the source of the smell at the molecular level, rather than mask it, like air fresheners or household items tend to do
