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Collectively, our findings suggest that menthol-flavored ENDS may alter respiratory homeostasis through the interaction of menthol and nicotine salt with nicotinic receptors, an effect that is attenuated in MMP12 KO mice, and highlights the significant involvement of flavoring chemicals, particularly menthol, in ENDS aerosol toxicity

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Breaking ranks with an administration bent on scrapping federal regulations, FDA Commissioner Scott Gottlieb described one possible policy scenario that would set a limit of 0.4 milligrams of nicotine per gram of tobacco

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