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Furthermore, some research suggests that long-term cannabis use may lead to a reduction of cannabinoid receptors in the amygdala, generally increasing susceptibility to anxiety [4]

There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052

These tools include nicotine replacement therapies such as nicotine patches, gums, lozenges, inhalers and nasal sprays, which are designed to help reduce withdrawal symptoms in a controlled way