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Signs of excess estrogen in women include: weight gain heavy periods fibroids PMS fibrocystic breasts loss of sex drive fatigue, depression, anxiety For men , too much estrogen leads to: gynecomastia sexual dysfunction loss of muscle mass fatigue, depression, anxiety Outside of estrogens essential role in reproduction, estrogen plays a key role in the control of energy metabolism.[ref] Getting rid of estrogen (breakdown and elimination): The level of estrogen in the body needs to be at the right level for the individuals age and sex