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Key factors are: adequate follow-up: it's ok motivating someone to quit for a week, but we're really interested in long-term abstinence chemical measures of abstinence: it's one thing for a participant to tell you they've quit, but the chemical tests of abstinence aren't subject to the same biases a control group: some studies only report data from a treatment group

ROS, 8-OHdG, and cotinine also correlated negatively with P2 levels