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Wellcome Trust Case Control C, Tyler-Smith C, Carter NP, Lee C, Scherer SW, Hurles ME, Origins and functional impact of copy number variation in the human genome

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Since we have shown that 5-HT 1A R antagonists and partial agonists attenuate adverse behavioral responses to antidepressants in adolescents, treatment for teen depression should take into consideration potential drug therapies with 5-HT 1A R antagonist activity to improve antidepressant efficacy, particularly during the initial period when adolescents are most vulnerable to the confounding effects of SSRI treatment

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