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Marty Makary, bowed to White House pressure by approving and widening the marketing for fruit-flavored e-cigarettes targeted at adolescents

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In 1560, Nicot sent powdered tobacco to the French court, claiming it had medicinal properties and could cure ailments such as migraines and colds

But a key challenge was to make nicotine palatable: The chemical had been used as an insecticide since colonial times, and three drops on the tongue could be lethal, according to Robert Proctor, a cigarette historian at Stanford