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Oral submucous fibrosis OSF is a chronic, insidious disease that affects the submucosa of the oral cavity resulting in progressive limitation of mouth opening which is a hallmark feature of this disease18

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[28] noted that in Bhatta and Glantzs analysis [31], the majority of EC users currently or formerly smoked: only 12 participants out of 17,601 used ECs but had never smoked cigarettes, and none of these 12 developed respiratory symptoms in the PATH waves examined