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A practical example often reported is the gradual onset of mild breathlessness during physical activity, which users may not associate with vaping because the change develops slowly

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Figure 7 shows the levels of isoprene, 1,3 butadiene, benzene and toluene in the third and fourth puffs from a 3R4F cigarette smoked with 35-mL, 2-s puffs taken every 30 s