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The findings of this review underscore a consistent and concerning pattern: across diverse geographic regions and study designs, e-cigarette use among children and adolescents is associated with a wide range of adverse health outcomes ( Despite these consistent trends, the generalizability of the findings must be interpreted with caution

All data are normalized to a common product definition and mapped to a consistent set of codes

While BO is rare, it is irreversible and difficult to treat once established

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