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If, for example, women participants had found smoking cessation more difficult to achieve than their male counterparts, this could provide an alternative explanation for their greater susceptibility to the detrimental effects of smoking due to greater total lifetime exposure

[63] [64] The National Institutes of Health, through the National Cancer Institute, determined in 1998 that "cigar smoking causes a variety of cancers including cancers of the oral cavity (lip, tongue, mouth, throat), esophagus, larynx, and lung." [65] Relative risk for cigar-only smokers of all-cause mortality is 1.02 for 1-2 cigars/day, 1.08 for 3-4 cigars/day, and 1.17 for 5+ cigars/day

The patch releases nicotine slowly over a 24-hour period, which is then absorbed through the skin and into the bloodstream