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Smoking 20 or more cigarettes a day is generally considered heavy smoking, but even fewer cigarettes can have serious health implications

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There are few if any attempts, however, to systematically and comprehensively evaluate the landscape of evidence on smoking risk across a diverse range of health outcomes, with most current research focusing on risk or attributable burden of smoking for a specific condition 7,15 , thereby missing the opportunity to provide a comprehensive picture of the health risk experienced by smokers

They hypothesize that this rise in incidence is related to the changes in cigarettes over the years that encourage deeper inhalation