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Adequate notice: The plan must clearly disclose all materials describing the terms of the program, notify participants of the reasonable alternative standard, provide contact information for obtaining it, and state that any recommendation of an individuals personal physician will be accommodated

It has also been challenging for national and international authorities to regulate these products given their unclear impact on health risks

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Accordingly, the results from our study let us hypothesise that CSC could be responsible for two main steps in the atherogenic process: (i) CSC induces endothelial cell death and therefore it could be responsible for endothelial damage on the vessel wall and (ii) CSC triggers the initiation of an inflammatory response through induction of necrotic cell death