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It can also constrict blood vessels, reducing the amount of oxygen-rich blood that reaches vital organs and tissues

This was a response to Big Tobaccos marketing of cigarettes branded as light or mild beginning in the 1960s that were later shown to be just as harmful as other cigarettes, in part because smokers compensate by inhaling them more deeply into their lungs

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However, this is likely an underestimate given the stigma around using tobacco while pregnant and the inconsistent assessment of e-cigarette use in healthcare settings