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According to 2008 research carried out by the American Psychological Association , "at least half of a person's susceptibility to drug addiction can be linked to genetic factors." Despite the many risks associated with smoking, and though it is thought to contribute to the deaths of 8 million people worldwide every year including 1.2 million who die from exposure to second-hand smoke tobacco remains widely available and easily accessible

Indicating a structuralfunctional relation, we observed that smoking-related gray matter decreases overlapped with the acute functional effects of nicotinic agonist administration in the left insula, ventromedial PFC, and mediodorsal thalamus

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