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Considering variations in coffee consumption among studies, we considered results from all degrees of coffee consumers and considered the no-exposure group a reference to determine the HRs

Although headaches associated with quitting smoking are usually mild and temporary, it is advisable to consult a healthcare professional if: the pain becomes particularly severe and interferes with daily activities, work or sleep

Emerging evidence indicates that rapid nicotine absorption may increase reinforcing effects, but systematic studies quantifying addictive potential are lacking (15)

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